产品货号：
Z38931
中文名称：
SHC/SHC1抗体
英文名称：
Anti-SHC/SHC1 Antibody (Clone#OTI3A1)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SHC/SHC1 Antibody (Clone#OTI3A1) |
| 指标别名 | SH2 domain protein C1;SHC;SHC transforming protein 1;SHC transforming protein 3;SHC transforming protein A;SHC1;SHCA |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF |
| 基因名称 | SHC1 |
| 克隆号 | OTI3A1 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Full length human recombinant protein of human SHC1 (NP_003020) produced in HEK293T cell. |
| 实际分子量 | 51.5KD |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | Signaling adapter that couples activated growth factor receptors to signaling pathway.Isoform p46Shc and isoform p52Shc,once phosphorylated,couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems.Isoform p66Shc does not mediate Ras activation,but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants,cytochrome c release and apoptosis.The expression of isoform p66Shc has been correlated with life span |
| Uniprot ID | P29353 |
| 基因名全称 | SHC (Src homology 2 domain containing) transforming protein 1 |
| 蛋白名全称 | SHC-transforming protein 1 |
| 推荐稀释比 | Western blot (WB) 1:2000 Immunohistochemistry in paraffin section (IHC) 1:50 Immunofluorescence (IF) 1:100 |
相关搜索：SHC/SHC1抗体，SHC抗体，SHC1单抗，Anti-SHC/SHC1 Antibody (Clone#OTI3A1)